Registry corruption since w2k is pretty much solved. It's a database with a WAL-style transaction log. If registry corruption is something that happens to you more than once, I'd check the storage since there's probably a lot more that's getting corrupted... Otherwise - keep full disk backups.
Chucking and restarting a VM is a lot faster than dealing with full disk backups.
Registry corruption isn’t just about transactional integrity. It’s also about whether or not something got misconfigured along the way and now you have to go figure it out. Or end up trying to uninstall and reinstall a bunch of stuff.
I’d rather just be able to start over from scratch.
All this work to treat our servers like cattle, but we insist on treating our clients like pets. Your local client should be just as replaceable as your servers.
It’s not so much corruption, it’s that every app uses it a little bit differently and half of them aren’t good at cleaning it up on uninstall. You can still get the system into a bad state where a rebuild (especially if you don’t have a lot of dependencies) is easier than trying to untangle whatever app or script or driver borked something.
