Genomes are much more than just their sequence. Their spatial organisation, their methylation, their fiolding, their packing etc, have no equivalents in a filesystem.
You're talking about a digital<->analog interface. Take a digitally encoded audio file, read it out and turn it into sound waves using a digital analog converter, play it out on physical speakers, record it back with a microphone, use that information to control a robotic arm with a magnet that will swipe over the physical medium... etc. They are absolutely analogous.
