Suicide drones (aka cruise missiles) have been on the forefront of any first strike mission the US have conducted in modern times with manned planes being relegated solely to roles where they need to drop larger quantities of cheap munitions or fly Close Air Support missions.

This of cause meant that the navy gradually took over the "first strike"/"suppression of air defenses" from the Air Force and the F-35 was born as an attempt to bring that back into the ranks of the Air force as stealth theoretically allows the F-35 to almost compete with submarine launched cruise missiles.

The problem is that the F-35 is way to expensive/fragile for the CAS role and might be so expensive to operate that it begins to make sense to depend entirely on missiles and drones for pre-planned strike missions, making it kind of the modern equivalent of post dreadnought battleships.

I think it will all come down to one plucky and very clever outsider who stumbled into the situation by accident. Oh yeah, and the girl who needs rescued from the system against which she has rebelled.

The thing is, if increased cyberwarfare capabilities allow you to exploit some large percentage of the drone force, then that would leave an extremely large gap to exploit by the enemy. If you can't fly drones because you risk them being crashed (or worse, turned on you), then you need some backup force. That might be real pilots, or it might be non-remote-controlled drones, or some combination of things like that.