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Psychedelic pharmacology pretty much ensures that the vast majority of people will not become physically addicted to the substances, as opposed to substances like nicotine, alcohol, opioids or amphetamines.

5-HT2A agonism induces a rapid tolerance, making it difficult to dose many times in a two week period. A second dose or more within that period will have vastly diminished returns.

Psychedelics can be addictive in the same way Magic: The Gathering can be addictive, but not so much in the same way that physically addictive drugs are.




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