I could see using something like this on a pedalboard in pedal form if you had the latency around <5ms or so for sure. I use a combination of analog and digital effects combined with analog amplifiers. I still prefer the actual amps quite a bit compared to simulations, but the simulations are a lot less of a pain. Recently I have been using a combination load box / cabinet simulator and I think those types of devices can really deliver in terms of tone and convenience.