It can lead to chronic stress. Chronic stress can kill in the worst case. I think Elon Musk is a good public example of what (chronic) stress can do despite being financially successful.
It's definitely way more stressful but it's a balance. I think having too little stress can be just as unhealthy as too much stress. Some amount of stress is necessary to feel engaged and important in the activities you work on. You can work at a big company and feel completely unnecessary to the world. As a founder, finding the balance is extremely difficult but a very rewarding journey if you can sustain it. There's a certain zen about finding peace and focus in a chaotic situation.
