meta:...and here come the downvotes for presenting factual information with no rebutal. I hate to say this is typical on HN, but it's definitely something that occurs in certain "hot-topic" discussions. A downvote here without rebutal is a bit like:"no! you're wrong!"
"based on what specifically?"
"you're just wrong!"
Common HN, we're above that kind of childishness...let's get specific.
Either nutmeg contains Myristicin, which is deadly at about .15 grams of the substance, which occurs in natural concentrations in nutmeg or it doesn't. (it does) We're not talking about car loads of the stuff.
A dosage of about a tablespoon of nutmeg contains a lethal amount of Myristicin, or it doesn't. (it does)
We appear to be in violent agreement about the percentages, dosages and other particulars, so what parts of my statement appears to be the problem?
For fun, I looked up some more:
Comprehensive Review in Toxicology for Emergency Clinicians, Bryson, P. D.
"The chemical agents which are thought to give nutmeg its psychoactive effects are myristicin and elemicin, which are amphetamine-like compounds similar to MDMA...The ingestion of as little as 1 to 2 tablespoonsful, which may contain 5 to 10g in each tablespoon, is capable or producing psychoactive effects described as hallucinations, euphoria, and other distortions of reality as well as many undesirable effects.
The symptoms begin 3 to 6 hours after ingestion and generally resolve in 24 hours. The first CNS effects are giddiness, tingling, dizziness, apprehension, anxiety, and a generalized feedling of excitement. Later, euphoria, visual hallucinations, distortions in time and space, reality detachment, sensations of limb loss, and fear of death may occur. This may progress to extreme drowsiness and lethargy that persist for a day or more."
And another from Emergency Medicine News
"The study itself conducted a retrospective chart review of the California Poison Control System electronic database for cases of isolated nutmeg exposure during the years 1997 – 2008. The authors identified 119 single-substance exposures, collected descriptive data, and compared intentional recreational abuse (86 cases) with unintentional exposures (33 cases)."
On Elemicin, the other psychoactive component of nutmeg.
"One study found it to comprise 2.4% of the fresh essential oil."
So nutmeg is probably toxic in slightly lower doses than I've been claiming, but it's hard to find specific toxicity studies that isolate both compounds.
"based on what specifically?"
"you're just wrong!"
Common HN, we're above that kind of childishness...let's get specific.
Either nutmeg contains Myristicin, which is deadly at about .15 grams of the substance, which occurs in natural concentrations in nutmeg or it doesn't. (it does) We're not talking about car loads of the stuff.
A dosage of about a tablespoon of nutmeg contains a lethal amount of Myristicin, or it doesn't. (it does)
We appear to be in violent agreement about the percentages, dosages and other particulars, so what parts of my statement appears to be the problem?
For fun, I looked up some more:
Comprehensive Review in Toxicology for Emergency Clinicians, Bryson, P. D.
"The chemical agents which are thought to give nutmeg its psychoactive effects are myristicin and elemicin, which are amphetamine-like compounds similar to MDMA...The ingestion of as little as 1 to 2 tablespoonsful, which may contain 5 to 10g in each tablespoon, is capable or producing psychoactive effects described as hallucinations, euphoria, and other distortions of reality as well as many undesirable effects.
The symptoms begin 3 to 6 hours after ingestion and generally resolve in 24 hours. The first CNS effects are giddiness, tingling, dizziness, apprehension, anxiety, and a generalized feedling of excitement. Later, euphoria, visual hallucinations, distortions in time and space, reality detachment, sensations of limb loss, and fear of death may occur. This may progress to extreme drowsiness and lethargy that persist for a day or more."
And another from Emergency Medicine News "The study itself conducted a retrospective chart review of the California Poison Control System electronic database for cases of isolated nutmeg exposure during the years 1997 – 2008. The authors identified 119 single-substance exposures, collected descriptive data, and compared intentional recreational abuse (86 cases) with unintentional exposures (33 cases)."
On Elemicin, the other psychoactive component of nutmeg.
http://en.wikipedia.org/wiki/Elemicin
"One study found it to comprise 2.4% of the fresh essential oil."
So nutmeg is probably toxic in slightly lower doses than I've been claiming, but it's hard to find specific toxicity studies that isolate both compounds.