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Yes, really. Typical vaccines are like $5 to $200 or so. And worst of all, usually just one or two doses.

For all the horror HIV has wrought, global spending on vaccine development for HIV has been around $1 billion a year for the last few years. In contrast, the USA federal government spends $3 billion a year for HIV antiviral drugs for low-income Americans. $20,000 per patient per year for life. Unsurprisingly, new antivirals are where most of the research is.

It can sound almost like a conspiracy if I put it like that, but it's just the economics incentives. Especially since the developed countries where most of the market for charging a decent markup is, have the smallest market for most new vaccines, while having the largest markets for therapeutics for chronic conditions.

Now HIV is genuinely devillish to develop a vaccine for despite our attempts. But vaccines for hepatitis C, gonorrhea, HSV, among others appear to be possible. We almost certainly could develop effective vaccines for these with existing techniques, if someone coughed up the funding. Maybe all the buzz about mRNA vaccines will spur some progress here.




> It can sound almost like a conspiracy if I put it like that, but it's just the economics incentives

Talk about market failures! It's completely obvious that this economical system is not placing the good of the whole human species as its first priority.


"es, really. Typical vaccines are like $5 to $200 or so"

But since the demand is 14 000 000 000 doses, there should still be a little bit of money in it?


Yes, clearly. With COVID-19, there is pretty much guaranteed market for about ten billion doses. Along with direct investment by governments in wealthier countries. Most people, including politicians, want a COVID-19 vaccine real bad.

The parent poster was describing the situation with vaccine development in general, to which COVID-19 is quite the exception. A potential hepatitis C vaccine for example has very different economics, as it would not be deployed anywhere nearly as widely or quickly. Consider that, 40 years after hepatitis B immunization became available, the majority of Americans haven't been jabbed with it.


Yes, but a pandemic only comes around every hundred years or so. Moderna happened to be in the right place at the right time for this one, but delivering vaccines for a pandemic is not much of a solid business plan.




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