Ah, that totally makes sense. In retrospect it totally makes sense that the aggressive inflammation reduction of high-dose corticosteroids could cause that. By analogy, it's well-known that animals (including humans ofc) exhibit "sickness behavior" where they are lethargic, avoid social interaction, etc, which is probably (a) an "intentional" adaptation and (b) can probably be explained largely by the increase in inflammation from the immune response