I'm left-handed and I'll take a built-in numpad any day. I punch in enough long numbers day-to-day to really enjoy having it, even if it's on the "wrong" side of the keyboard (and so it is with virtually every other keyboard out there with a built-in numpad).
I also already normally type with my keyboard slightly off-center on my desktop, so an asymmetrical laptop keyboard ain't really all that big of a deal. Even if I didn't, and insisted on a perfectly-centered typing experience, having an off-center screen is something that I've yet to actually really notice.