Like anything it's going to heavily depend on latency to the workstation in question. With cloud providers that have reasonable region coverage, it's not really that bad. In our tests, ~40ms latency is the upper bound of where you want to be before artists start really complaining, and Teradici themselves suggest 25ms for optimal results. However, depending on the task said artist is doing, you can venture above that, though for Cintiq/pen displays it becomes pretty painful and a "live with it" type deal.