Re "safe setting": As with any psychedelics, always experiment with a sober friend.
You'll talk utter nonsense at them for a few hours, but they can walk you around, talk you out of anything stupid and calm you down if you see anything that scares you.
A microdose should not need a sober friend and should not cause you to talk utter nonsense. The colloquial definition of microdose here is "that which has sub-cognitive effects". Its generally between 0.05 and 0.1 grams for cubensis strains of mushrooms.
You'll talk utter nonsense at them for a few hours, but they can walk you around, talk you out of anything stupid and calm you down if you see anything that scares you.