A smart way of going about it would be to just implement ratelimits based on human ability of clicking a mouse button - I'm sure no human is able to click a button 100 times a second. And of course ban people that are consistently at the gates of the ratelimit.
I got to think a bit more on that ... and: what about doing the complete opposite? i.e to encourage automatic clicks with the final goal of making stonks go even more up?