Midnight Request Line was the first dubstep song to go mainstream (IIRC Annie Mac picked it up), but the genre existed before that point. It's a great song though.

Annie Mac made dubstep go mainstream? TIL.

Side anecdote... My oldest bro was in a band with her brother Davey in school and my second oldest bro was in her class.

Oh I know, I’ve got the first few DMZ releases on vinyl but that seems like the first track that started to hit public consciousness.