It's amazing really. I was playing the original Theme Hospital (1997) just yesterday on Windows 10 with no issues[1].
[1] Okay a couple of issues. It needs compatibility mode for the colours to look right. But that option is built into Windows so I don't really consider that a failure of compatibility. And the installer is 16-bit and won't run on 64-bit windows. But some years ago I made a copy of it after install and the actual installed game is 32-bit and runs fine.
For a lot of those 16bit installers, WineVDM works wonders. https://github.com/otya128/winevdm It's not perfect compatibility for all 16bit programs but it does tend to work well enough at anything I've thrown at it.
[1] Okay a couple of issues. It needs compatibility mode for the colours to look right. But that option is built into Windows so I don't really consider that a failure of compatibility. And the installer is 16-bit and won't run on 64-bit windows. But some years ago I made a copy of it after install and the actual installed game is 32-bit and runs fine.