I generally avoid them for reference books, but for novels since I very rarely re-read them. I'm willing to make the trade-off for convenience and (sometimes) lower prices, but I go into it eyes open knowing the risks.

I do worry about things like Steam though, which unless the game is available DRM-free from GOG, may be the only place you can buy the game-- or at least no different in terms of DRM lock in and risk of the platform shutting down than other platforms like Epic or Origin etc.