I have. There was a Chrome version (69 IIRC) that kept it from using a proxy server that was at a CNAME and had Kerberos authentication.

Here: https://bugs.chromium.org/p/chromium/issues/detail?id=872665

This was a huge, huge, huge pain in the butt in a big enterprise. Nothing like a creeping "users can no longer access the internet" spreading across the environment.