This was definitely one of the most iconic moments in any video game I've played, I don't think anyone who's been through the game will forget that song/mission combo.

I just watched it on YouTube and, at the risk of sounding like a fuddy duddy, I don't get it. Looks like you just point a flamethrower at the weed or blow something up near it, and watch it burn. I mean it looks cool but what makes it stand out as an all-time great gaming moment?

It’s the experience of doing it that makes it special. There’s no good way to put that into words.

Guess I'll have to try it.

What makes it stand out is that in game this is the mission where the transformation of the protagonist from the normal person to killing machine begins. If you ever play the game, the contrast in dialogues from the opening scene and this scene can be actually felt by the player. The player themselves feel empowered after finishing this mission. Also the soundtrack in this particular mission hightens that feeling. TL;DR: Play the game and you will definitely like it.

Cool. I'll pick it up.

There's also The Wolf by Fever Ray in Far Cry: Primal, creating one of these gameplay moments when you start to doubt you're not hallucinating.

What triggers that?

That was definitely a scripted sound cue, a pretty fun moment for sure!