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> So they are aware of the possibility of this effect, yet didn’t bother with it. Sounds like replication crisis to me.

No, that is doing small study correctly.

The whole point of small scale studies is to figure out whether paying for bigger one is waste of time and money. Randomized clinical trials are expensive. There is no point of doing them if small studies dont show effect. However, if you do small study, it is correct to point out limitations.




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