Wikipedia page for the compound: https://en.wikipedia.org/wiki/ISRIB

We keep seeing these types of headlines. Anyone familiar with these types of studies know what the progression is after testing on mice? That's all we hear about and I'm wondering what portion of time, funding, failure rates it is that we don't see the studies progress to pigs, chimps, or humans. What's the actual procedure here? And why don't we see next steps?

Seems simple enough to synthesize. I expect it to show up on the nootropics market in 3...2...1...

Given the study mice “received an intraperitoneal injection of 2.5x their body weight” [1], it would require heavy at-home DIY doctoring.

[1] https://elifesciences.org/articles/62048

2.5x? That must be an error?

Cool thing is that they first dissolved it in DMSO, which can make a great carrier for transdermal absorption.

Hopefully! Better nootropics are needed!

It does seem to be quite expensive from chemical suppliers. We really need to solve that protein folding problem so chemicals can just get synthesized through protein factories...

Flowers For Algernon.

> Flowers For Algernon

With a twist, given that the drugs were given to the mice here ;-)

> Rapid Rejuvenation of Mental Faculties in Aged Mice

Just say “in mice”

https://mobile.twitter.com/justsaysinmice

I like to add "with mice, who have 97.5 percent of working DNA in common with humans."

lol thats what I said outloud when I read the title

Like what you say after reading any fortune cookie

It's a good thing I'm a mouse. I've been alive for nearly 150 years at this point, my eyesight is stellar, and my cancer has been cured over 40 times!

_Glances over at the mice in the control groups and failed experiments_