I'm also seeing significant stuttering on Twitter on Big Sur on Safari 14.0.1. Chrome scrolls smoothly in comparison. Same deal on Reddit.
Then again it was still the case before Big Sur and Safari 14, so I can't call it a regression.
There was something with UBlock or Adblock Plus in the past and if it wasn't UBO I wasn't sure if they were trust worthy. I think one went rogue and one started selling the ability to unblock ads. But, with Safari 14 being able to transform chrome extensions, I hope that some of the popular ones and EFF ones can migrate.
I ended up migrating to Better as it uses Apple's API for this(I think it's a list of things to block), is OSS, and Apple seemed to be helping them with a change of ownership publicly and that lended some trust.
The short answer is that uBlock Origin is what almost all users are likely to want.
uBlock (without Origin in the name) is property of the same owners as AdBlock Plus, and both extensions whitelist ads under their owners' "Acceptable Ads" program, with many of the advertisers paying for that special access.
So I am torn between the two.