You still have to deal with a 6/3 hard-right supreme court, courts packed to the gill with FedSoc pasties, and most likely (though depending on a GA runoff) the same senate which basically gridlocked Obama's second term and prepared the grounds for Trump's term.
There are enough other Republicans in the Senate from safe states that I'm sure one of them would be happy to play obstructist on any Democrat policy. Eliminating any one senator without gaining majority is just a morale victory.
My prediction is that McConnell retires. Without a willing patsy to play against, there is not much to be gained by staying in office. He rammed a court nomination through, mission accomplished.