Most of my team is global, just a handful of people are located in the same city as I am. We have a yearly F2F, it is very expensive and disturbing to get people from around the world (literally), get visas, fly them into a place. Because the cost, everyone wants "to make the most" out of it, resulting in stupid, meaningless meetings focused on "building the organization", making the cost/benefit even worse.

I had a colleague that worked alone in a remote place (~8 hours drive from nearest office) for 15 years. He did not went nuts, that's the best I can say about his situation.