yeah. I've done a little bit (tiny, inconsequential, not an expert) with satellites. When cosmic rays have enough energy they'll move atoms around. That's bad for gates. A 486, old big gates, doesn't hurt much. maybe you have to reboot every few days. Tiny little 2 atom gates, they're more delicate. think plastic vs glass glassware. With plastic you can have a few incidents and it'll still be a glass. with glass, it's a lot easier to chip an edge or shatter and not be usable anymore. Again, not my area. But I suspect altitude is really bad for tiny systems because they lose so much "free" shielding.