I have mixed feelings about the quote, at least as far as I understand it or have heard it interpreted.

Specifically when it comes to systematic change, be that in a code base, a companies organisation or a countries political system. The mindsets of people go trough the spectrum of such systems being as easy to change as snipping a finger (and that doing so is a good idea) to it being impossible or dangerous so you should not even try.

From my perspective, pretty much anything can be changed in any direction. But it might take enormous effort to do so, way more than one could do alone and I might not even be around anymore when the change "finishes". While I could think of a hundred things that I would like to change or actually resist change, I only have the time and energy to focus on one or two at a time.

So for me, having overworked myself in the past, it boils down to consciously think of what I should and can burden myself with, when I should give up something and what the realistic outcomes are to find a good mix between ambition, effectiveness and health.