Instantiation and teardown aren’t hard, or at any rate they shouldn’t have to be. If you roll this stuff by hand, it can often indicate weak areas of the design -- unnecessarily tedious boilerplate that can be cleaned up.

To me, DI frameworks are usually an example of the tail wagging the dog. You make your code more complex, slower and harder to debug just for the sake of making it more testable. But if you avoid leaning too hard on the framework, it’s usually possible to keep the design clean and get good test coverage. In fact you can often get better test coverage, by using real components rather than being tempted into relying on mocks.