I guess different work patterns work differently for different people. I've been using tmux exclusively on my local machine (much less often on remote machines) for the last 2+ years, and it really works well for me. On a daily basis I tend to work in a lot of different contexts, so having scroll-back buffer and bash history nicely organized so I can switch from task to task, with clean restoration of the scrollback/bash history for each environment when I reboot my computer to update it is a godsend. I also like having the various parallel running tasks for a particular environment (like an ssh, log tail, commands) - all running in different panes in a single window - so I never have to go looking for them.

One change I made was forcing myself to always name a window when it gets created - that way I can usually hotkey back into an environment by its name, rather than having to go searching for windows.

I particularly like that I can use exactly the same toolset on my Mac, Windows, and Linux clients.