As an example (the only case that I've identified personally), if your curious, I have a (windows; Intel q6600) box that I use for gaming occasionally. Single player game I like, Total War: Shogun 2, runs at about 55 fps (benchmark) pre-Meltdown/Spectre/etc. Now it gets ~22 fps. I can use https://www.grc.com/inspectre.htm to toggle some mitigations to get it playable again.