Edit: I will add that I am also, no doubt, basing it off of background knowledge about cell function. For example, mitochondria change and develop greater capacity to process X if you consume a lot of it, which is part of the addiction process and part of why withdrawal is a thing. If you consume a lot of, say, alcohol, you need to ramp down gradually so that the body can make changes at the cellular level to adjust to the lesser amount of alcohol and this is part of why cold turkey is so very hard and it is generally recommended that you taper off.
I used to ask smart people with PhDs and the like a lot of questions about cell function and read what I could get my hands on that could be followed by a lay person because I have a genetic disorder that impacts cell function.
