I would recommend the author to try NixOS instead. It is not like that you wouldn't have issues however mostly things works (never had the kind of issue the author reported in this post, for example).

I think the difference between NixOS and Guix, excluding the language of choice of course, is that NixOS has the community to make it work. For example, I had a issue last night that I opened a issue in GitHub, and in a few hours the maintainer of the problematic package answered me and the problem was fixed.