Having a cute API and leaving the parentheses out of your function calls isn't a DSL, it's just a cute API where you leave the parentheses off. I know Ruby people call them "DSLs" all the time, but they aren't.
Python doesn't have an idiomatic equivalent to block arguments, but you could probably write an equally usable routing API. It just wouldn't look as cute because there would still be parentheses.
What you end up doing in e.g. Flask is decorating your controlle method with the path that routes to it. Turbogears controllers serve routes based on class and method names without the extra wiring that Rails has. Django has a Rails-style "URLconf" (https://docs.djangoproject.com/en/2.2/topics/http/urls/) that actually seems a lot more intuitive and explicit to me.
