I for long searched for a way to use GTK from nodejs. There are some proof of concept level bindings, but none exposing any much decent amount of the underlying functionality.
Why would you want to do that? Isn't the point of Node that you get a powerful GUI system but the tradeoff is that you have to use Javascript (or Typescript) instead of a nicer language?
Some people like working in javascript, or it's just what they know. I would agree, though, that it's hard to make an argument for JS in that context on its technical merit. Even with the power and universality of a browser rendering engine, I think JS on the desktop is a disappointingly hacky way to avoid investment in purpose built cross platform UI toolkits. (Either building better ones or hiring people who know how to use existing ones.)
Same for Qt I think