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Not an expert, but for example maybe decoding the TCG instruction (in the ribosome) is slower or uses more energy.



I doubt that's the only reason but according to this table [0], AGC triplets are 2x more prevalent than UGC in that bacteria.

Edit: this the frequency of that codon being used o the genome sequence. But the assumption could be that it is also preferably produced as a t-RNA so it can replicate its genome efficiently.

It's more likely that they have introduced errors, or non-preferred patterns, which affect the number of replication forks and stall the replication machinery.

[0] https://www.kazusa.or.jp/codon/cgi-bin/showcodon.cgi?species...




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