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Berberine has been shown to be as effective as metformin at controlling blood sugar with additional anti-depressive benefits.

https://examine.com/supplements/berberine/




I don't think it's comparable. That link overstates the amount of evidence. Notably the only good trial didn't compare it to metformin. Three small trials and a meta analysis. There is decades of experience with and significant evidence for the efficacy of metformin.




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