Nope. The weird Bluetooth audio standards that cause these issues (the entire headset switches modes sometimes just because the microphone is switched) don't apply to wired inputs in my experience.

Unfortunately, this problem isn't _exclusive_ to AirPods though... it has happened with a few other Bluetooth headsets I've used too. I don't seem to have ever had this issue on my iPad or iPhone, though I can't run VMs on them either :)