- Safari
A lot of people run web browsers.
- Firefox (streaming audio)
A lot of people stream audio.
- A program converting a 500 page PDF to 500 300dpi PNGs
That's a weird one, sure.
- A bash script extracting PDFs from a municipal web site.
Also weird, but "average people" need to do some kind of automation once in a blue moon, so let's not discount that.
- A program downloading my video viewing for the week and converting it to a format better suited for my iPad
The conversion is unusual, but people download videos to their iPad.
- iTunes serving audio and video to TVs in two different rooms
A little niche, but "media server" is still a thing.
- An FTP program doing weekly backups
Backups are a thing. A thing more people should be doing, but definitely a thing.
- A mail client
Not niche at all.
- A VPN client
Not niche if your office requires a VPN. A lot do.
- A spreadsheet
Definitely not niche.
- An IDE (Coda2)
Sorta niche-y, but think of it as "text editor" and it's less so: it could be a word processor, or Scrivener.