You can use an other implementation of preprocessor for C/C++, with more features, e.g. DMS[0], which works with AST, or even PHP or Perl, but you will need to parse code twice, so compilation will be about 2x slower.
In C(++), the preprocessing is only way to portably declare directives. All others are vendor-specific. They are working on a common directive and module system now, but it will take at least two more years to be standardised fully.
[0]: http://www.semanticdesigns.com/Products/DMS/DMSToolkit.html