While I think Marco probably has it right long-term, I think he's actually pretty wrong in the short-term. The difficulty of porting an iOS app (or even writing a Mac app from scratch, given that a developer only has iOS experience) and the nature of the device (mobile is clearly a growing market--is the same true for the desktop?) means that I think we'll see a lot more trepidation in entering the Mac App Store.
Traditional Mac developers (Panic, Omni, etc.) will obviously move their apps onto the store, but I don't think we'll see a whole lot of new entries--most iOS apps don't neatly transition onto the desktop, besides some games. I know my couple iOS applications don't have an obvious Mac version, just as my Mac applications didn't have an obvious iOS version. If the Mac App Store is to reach anywhere near the popularity of the iOS App Store, it's going to take a long time for companies to decide that the desktop is even worth it.
If Panic and Omni find that all they have done is reduce their revenue by 30% then they won't stay long. I'm not at all sure the extra volume will be enough to offset the cost, especially if the store becomes full. It is going to be interesting.
Your ignoring the other things you get from the app store. You need to compare the 30% cut apple takes off the top to the possible increased volume of sales, the money saved from not having to host the app yourself or having to run your own payment system. Apple is not just taking 30% off the top to just to be greedy, it is more of a payment for the service they are providing.
If you have anywhere near a reasonable volume your payment processing shouldn't cost more than a few percent, nowhere near 30%.
Hosting costs aren't going to go away, you will still need a web site, you might be able to save a little download bandwidth but that hardly breaks the bank nowadays.
I don't think Apple are being greedy, I'm sure that is a reasonable reflection of their costs, I just wonder how it will add up for developers like Panic or Omnigroup. If their volumes double then it makes sense, if they only increase slightly or not at all then it doesn't.
I think that's entirely the wrong way of looking at it. This removes payment processing, download costs and (critically) installation support and serial number issues hassles.
But that isn't really what you're paying Apple for. You're paying them for the creation of a new market that may (or may not) be better for you. Discovery (formerly marketing) is going to largely be their thing. Customer education will become standardized. Trust - they will teach people that apps are safe and hassle free to install & uninstall. They will teach consumers what an app is.
This will probably amount to far more then an increase/decrease in sales. It will determine which apps succeed and fail. These will be different from the winners and losers in the existing, "natural" market. It will determine aggregate demand for apps. This will also be different. It will affect consumers' expectation for what an app should be. For example, I think that learning curves will need to be reduced. The concept of learning software will be reduced.
A lot of existing software (the big names: MS Office, Adobe CS, etc come to mind immediately) probably won't fit into the app mold comfortably. Developers will have strong incentive to create apps that do. It will be interesting how much software can be "apps."
The app store only increases your sales by any significant amount if you get featured by apple or you break into a top 100 list. Now a days, to reach the top lists and to show up on apples radar, you need some sort of external marketing and exert a downward pressure on your prices. If your going to do external marketing you might as well try selling through a more profitable venue.
Traditional Mac developers (Panic, Omni, etc.) will obviously move their apps onto the store, but I don't think we'll see a whole lot of new entries--most iOS apps don't neatly transition onto the desktop, besides some games. I know my couple iOS applications don't have an obvious Mac version, just as my Mac applications didn't have an obvious iOS version. If the Mac App Store is to reach anywhere near the popularity of the iOS App Store, it's going to take a long time for companies to decide that the desktop is even worth it.