I stick with the default Windows Defender feature because it's actually pretty comprehensive. If you have Avast or McAfee on your computer, I'm going to judge you.

If I know I have something, usually it's because I permit it through Windows Defender and experimenting with problematic file types, then I use Malwarebytes. I also take a good hard look at my programs lists and remove ones I don't need, review my start up programs, and etc.