H. pylori was first discovered in the stomachs of patients with gastritis and ulcers in 1982 by Drs. Barry Marshall and Robin Warren of Perth, Western Australia. At the time, the conventional thinking was that no bacterium could live in the acid environment of the human stomach. In recognition of their discovery, Marshall and Warren were awarded the 2005 Nobel Prize in Physiology or Medicine.
To test this controversial idea, Marshall self-administered the bacterium and developed an ulcer:
Unable to make his case in studies with lab mice (because H. pylori affects only primates) and prohibited from experimenting on people, Marshall grew desperate. Finally he ran an experiment on the only human patient he could ethically recruit: himself. He took some H. pylori from the gut of an ailing patient, stirred it into a broth, and drank it. As the days passed, he developed gastritis, the precursor to an ulcer: He started vomiting, his breath began to stink, and he felt sick and exhausted. Back in the lab, he biopsied his own gut, culturing H. pylori and proving unequivocally that bacteria were the underlying cause of ulcers.
> sero-positivity was associated with an 11% increased odds of CRC (OR, 1.11; 95% CI, 1.01–1.22), and this association was particularly strong among African Americans (OR, 1.45; 95% CI, 1.08–1.95)
These confidence intervals don't exactly instill confidence... Oh and we cherry picked this subpopulation where the effect is all over the place with a bigger mean.
You're getting downvotes, but that subpop figure is exactly the kind of thing that gets headlines and is disproven the moment someone tries to reproduce it. Why publish it?
I used to research h. pylori infections. Please finish any antibiotic courses prescribed. Antibiotic-resistant h. pylori sucks and is much more difficult and expensive to treat.
https://en.wikipedia.org/wiki/Helicobacter_pylori
To test this controversial idea, Marshall self-administered the bacterium and developed an ulcer:
Unable to make his case in studies with lab mice (because H. pylori affects only primates) and prohibited from experimenting on people, Marshall grew desperate. Finally he ran an experiment on the only human patient he could ethically recruit: himself. He took some H. pylori from the gut of an ailing patient, stirred it into a broth, and drank it. As the days passed, he developed gastritis, the precursor to an ulcer: He started vomiting, his breath began to stink, and he felt sick and exhausted. Back in the lab, he biopsied his own gut, culturing H. pylori and proving unequivocally that bacteria were the underlying cause of ulcers.
http://discovermagazine.com/2010/mar/07-dr-drank-broth-gave-...