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deugtniet
on Oct 14, 2018
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MPEG-G: the ugly
Probably that certain base sequences are more likely to occur together than random. If you account for this, it'll help in your compression.
pdkl95
on Oct 14, 2018
[–]
That's right - the Huffman tree was built based on the base frequency of use, which actually varies depending on what type of organism you're sequencing[1].
[1]
https://en.wikipedia.org/wiki/GC-content#Among-genome_variat...
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