All advice I've seen regarding the substance is to not take it more than once every 3 months. I think people just need to realize it really isn't a party drug you can take every or every other weekend. Not only will tolerance build very rapidly, but you're exposing your brain to excessive oxidative stress and overheating, and are likely causing serotonergic neurotoxicity (even if you take it with all the recommended supplements).

It needs to be treated like a rare, therapeutic, and special vacation, not something you take whenever you want to have fun.