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> first appears when a carrier is late in life

Not disagreeing with you I don’t think, I’d call it disease appearance to happen at middle age at best. Plenty have visible symptoms in their 20s though usually it’s in their 30s and 40s. Death is usually sometime around 20 years after onset of symptoms, though earlier onset often means earlier death. This is apart from the suicide risk, which is markedly increased. It’s about as awful a disease as one can have.



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