But time and money is a real constraint for projects. It's hard enough writing native Android, native iOS, and a web app to boot without also having to write native Mac, Linux, and Windows and dealing with all the cross platform UI quirks on Qt.
This is in reference to using Electron so you don't have to both write a web app and a native desktop app using Qt (in addition to native mobile, where performance issues are much more noticeable).
Any OS-quirks you experience with Qt are likely the nature of cross-development (path separators, toolbars, sys-trays), stuff that you'd likely experience with any framework.