There's an entire class of drugs which shuts down migraines by dilating blood vessels in the brain. https://en.wikipedia.org/wiki/Triptan - it's not a coincidence that these drugs target the 5-HT1B and 1D family of receptors (LSD targets 5-HT1A as an agonist, and it's thought to cause some of the stimulant effects of LSD)
LSD doesn't "cure" migraines, there will never be a trial. It will stop migraines, but so will triptans, and you know, without the side-effect of wiggin' nuts.
Triptans are awful. 0/10, pure awfulness in pill form.
Oddly, along with three prophylactic meds, I seem to be able to abort migraines with 1/4 tsp ginger powder dissolved in a cup of water. I doubt the ginger would help without everything else though.
Triptans do not abort my migraines. Hell, I suspect placebo might even outperform them for me.
The worst part: you pretty much have to pay a $1000 tax if you present at the ER with a migraine, because they will not believe you. People will be in a rush, they will not examine the giant history in the EHR spanning years and years, and you will be likely be suspected of drug seeking. So you have to say yes. $250 for a useless injection of sumatriptan and $750 for an hour of continuing to lie in pain on a bed until they hopefully realize you're telling the truth.
The worst part, they basically put your body into a state resembling a stroke or heart attack (forget which). Taking them is rolling the dice on one of those life threatening conditions with a nonlinear combination factor. Scary stuff.
LSD doesn't "cure" migraines, there will never be a trial. It will stop migraines, but so will triptans, and you know, without the side-effect of wiggin' nuts.