> With that in mind, we went looking for an option to host the Basecamp database, which is becoming a monster. As of this writing, the database is 325GB and handles several thousand queries per second at peak times.
HP sells servers with up to 64 cores and 2 TB of memory. Considering the car that DHH just bought himself, they should be able to buy/lease several of them.
You can get servers that can house 512GB or 1TB of RAM from HP/Sun/Dell. Scaling out your app servers and scaling up your DB is common in systems that don't need to be truly "web scale".