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I have shown that in elderly individuals essentially the entire epidermis stem cell compartment, whilst having normal morphology, is occupied by clonally expanded mutant stem cells:-

https://www.nature.com/articles/s41467-017-00993-8




That sounds very interesting, but after glancing at your figures, I don't see where you make this obvious.

Also, in the intro you say "the risk of skin cancer increases exponentially with age and is associated with accumulation of somatic mutations8". Your source groups ages into only 3 categories... If you look closer at the data you will see that developing most cancers becomes less common in old age (peaks at 60 - 90 years old). For cancers involving tissue like bone or reproductive organs this peaks much earlier, probably due to when the majority of cell divisions are occurring.




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