If you get high latency on a Linux machine when doing audio stuff you probably have hardware problems or software is misconfigured. Years ago I moved everything I had under XP (Reaper+plugins) to a Wine directory, reinstalling those plugins that didn't like to be moved, and never looked back. I'm using the kxstudio repositories software (RT kernel, Wine etc). http://kxstudio.linuxaudio.org/
Latency is very low, even on old PCs such as Core Duo ones, and compatibility is very high.
The only problem I encountered with Reaper under Wine is that it needs a lot of time to buffer a very big audio track when it's being added to a project. Say I record my band on our portable recorder then I drag and drop the big sample (2-3 hours stereo 44.1khz x16bit stereo uncompressed .wav) on a Reaper track, it starts eating all PC's memory to buffer it hanging the machine for a a good minute. Once the track is added, the memory gets released and it works perfectly though, so it's not technically a bug and I have no idea if it depends on Wine or Reaper.
A few months ago I also started to use the native Linux Reaper port which is fantastic and lately got a lot more stable, but all my attempts to have Windows plugins working in parallel with it through Wine failed although they say it is possible, so although there are some interesting plugins out there, they're not remotely comparable to what is available for Windows (but that would be the case for every other native application): using Wine is still the best option if you are not just strictly recording and need external plugins. I also explored the possibility to have musical software working on a Windows VM with disconforting results so far: computing power is there, but latency is a nightmare. As of today, to me Wine still offers the best options if one needs both low latency and compatibility.
The only problem I encountered with Reaper under Wine is that it needs a lot of time to buffer a very big audio track when it's being added to a project. Say I record my band on our portable recorder then I drag and drop the big sample (2-3 hours stereo 44.1khz x16bit stereo uncompressed .wav) on a Reaper track, it starts eating all PC's memory to buffer it hanging the machine for a a good minute. Once the track is added, the memory gets released and it works perfectly though, so it's not technically a bug and I have no idea if it depends on Wine or Reaper.
A few months ago I also started to use the native Linux Reaper port which is fantastic and lately got a lot more stable, but all my attempts to have Windows plugins working in parallel with it through Wine failed although they say it is possible, so although there are some interesting plugins out there, they're not remotely comparable to what is available for Windows (but that would be the case for every other native application): using Wine is still the best option if you are not just strictly recording and need external plugins. I also explored the possibility to have musical software working on a Windows VM with disconforting results so far: computing power is there, but latency is a nightmare. As of today, to me Wine still offers the best options if one needs both low latency and compatibility.