So does donating blood on a regular basis reduce vaccine efficacy over time? It seems you'd be giving away the T-cells. For a person with 8 pints of blood, making 5 one pint donations would reduce the number of original T-cells by about half. Unless there is a storage place for them. Do these have an affinity for hanging out in the spleen compared to other cells? That would prevent their loss during bleeding.
Yes, the spleen is one location for lymphocytes to hang out, as well as lymph nodes and other locations. Memory B cells will retain their immunologic memory so you can quickly create the antibodies for pathogens after vaccination. I doubt vaccine efficacy would change much as a result.
Looked at the paper, answer: that's what happens when vulgarization of scientific discoveries is so bad that it removes the actual discovery from the paper. Apparently the author discovered the existence of memory t cells when writing that article.
You are saying that you learned about the mechanism of the cellular memory?
This study found that one way the pool is maintained for years after vaccination is through the development of several unique features. On the surface and through the actions of their genes, they look like cells that have never been exposed to an infection, but on their DNA the researchers found a fingerprint, called a methylation pattern, that identifies them as having been through battle as an infection-fighting cell, which are called effector cells.
