Malaria was effectively eradicated in all but the poorest areas in the 1950s and 60s through vector management: indoor residual spraying, building better houses, eradicating still water near population centers.

The same can be done in sub-Saharan Africa (the main place it remains). In fact, in the richer areas of these countries, Malaria has a very low prevalence.

It's a disease of poverty. Drugs help, but it's mostly about the vector.